Gallbladder disease
Conditions
Interventions
Control group :The control group received volume-matched 0.9% saline infusions at identical rates.
Low-dose dexmedetomidine group: The low-dose dexmedetomidine group received a 75 µg/h loading dose over 15 minutes, followed by 60 µg/h maintenance infusion intravenously.
High-dose dexmedetomidinegroup: The high-dose dexmedetomidine group received a 150 µg/h loading dose over 15 minutes, followed by 120 µg/h maintenance infusion intravenously.
Sponsors
Fujian Provincial Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-45 years. 2. American Society of Anesthesiologists (ASA) grade I - II. 3. Patients undergoing elective laparoscopic cholecystectomy.
Exclusion criteria
Exclusion criteria: 1. Inability to provide informed consent; 2. History of chronic pain or substance abuse; 3. Pregnancy; 4. Body mass index (BMI) >= 30 kg/m2; 5. Known allergies to the study medications; 6. Intake of medications within the last 72 hours that potential interfere with the determination of the MACBAR; 7. Any other condition deemed exclusionary by the investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Minimum alveolar concentration to block the adrenergic response (MAC-BAR); | — |
Secondary
| Measure | Time frame |
|---|---|
| Hemodynamic parameters; | — |
Countries
China
Contacts
Public ContactLi Junyu
Fujian Provincial Hospital
Outcome results
None listed