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Clinical efficacy and mechanism of oropharyngeal probiotic DSM 34540 in the adjuvant treatment of acute upper respiratory tract infections and prevention of secondary bacterial infections in children

Clinical efficacy and mechanism of oropharyngeal probiotic DSM 34540 in the adjuvant treatment of acute upper respiratory tract infections and prevention of secondary bacterial infections in children

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300071252
Enrollment
Unknown
Registered
2023-05-09
Start date
2023-06-01
Completion date
Unknown
Last updated
2023-06-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute upper respiratory tract infection

Interventions

Intervention group:Under the premise of normal treatment, probiotic intervention was applied. After brushing their teeth every morning, noon and evening, the children took a probiotic buccal tablet an

Sponsors

School of Medicine, Wuhan University of Science and Technology
Lead Sponsor

Eligibility

Sex/Gender
All
Age
5 Years to 12 Years

Inclusion criteria

Inclusion criteria: 1. Children aged 5-12 years, school-age children attending kindergarten or school; 2. At the time of presentation, the child has had a current episode of acute upper respiratory tract infection for 2 days or less; 3. Parents/guardians have signed a written informed consent.

Exclusion criteria

Exclusion criteria: 1. Immune dysfunction or deficiency. 2. The tonsils have been removed. 3. History of rheumatic diseases. 4. Have bronchospasm and/or asthma F and/or allergic rhinitis. 5. Allergic to cow's milk protein. 6. Patients with respiratory diseases, systemic diseases such as diabetes, kidney disease, gastrointestinal disease, chronic sinusitis. 7. Have an infectious disease such as measles, mumps or rubella. 8. Antibiotics have been used in the last 7 days. 9. Use of immunosuppressant drugs (including oral or nasal steroids) within the last 30 days. 10. Take other probiotic products within the last 14 days.

Design outcomes

Primary

MeasureTime frame
Cytokines in saliva;Flora in saliva;Metabolites in saliva;

Countries

China

Contacts

Public ContactWang Qiang

School of Medicine, Wuhan University of Science and Technology

wangqiang@wust.edu.cn+86 159 7150 9779

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026