nasopharyngeal carcinoma
Conditions
Interventions
Experimental group:1. Do not irradiate the lower neck lymphatic drainage area of patients without lymph node metastasis
2. Reduce the dose of CTVn-2 to 57Gy.
Control group:1. Adopting the traditional plan of our center, prophylactic irradiation is performed on the lower neck lymphatic drainage area of patients without lymph node metastasis
2. The dose of CTVn-2 is 60Gy.
Sponsors
The First Medical Center, Chinese PLA General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. The primary tumor was nasopharyngeal carcinoma, and the pathological type was keratinous squamous carcinoma or non-keratinous carcinoma; 2. The tumor had a definite pathological diagnosis, and the clinical stage (according to the 8th edition of UICC/AJCC staging system) was T1-4 N1-3 M0, but did not contain T1-2 N0 M0 nasopharyngeal carcinoma; 3. Treatment mode: induction chemotherapy + concurrent chemoradiotherapy; 4. Functional status Score (KPS) >=70 points, physical status score (ECOG) :0-1 points; 5. Aged 18-70 years; 6. Normal liver and kidney function, no serious hematological system toxicity and serious medical complications; 7. No surgical intervention was performed; 8. Voluntarily participate in and sign informed consent in person.
Exclusion criteria
Exclusion criteria: 1. Previous history of head and neck radiotherapy; 2. Patients with other malignant tumors; 3. Claustrophobia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Regional recurrence free survival rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Radiotherapy related toxic side effects; | — |
Countries
China
Contacts
Public ContactMa Lin
The First Medical Center, Chinese PLA General Hospital
Outcome results
None listed