Anticancer targeted drugs-related skin side effects
Conditions
Interventions
Experimental group:Shouzuping + urea ointment
Control group:Placebo + urea ointment
Sponsors
Fangshan Hospital Beijing University of Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Patients who have been pathologically diagnosed as malignant tumors and are receiving targeted angiogenesis inhibitors; 2. HFSR associated with angiogenesis inhibitors; 3. Aged 18-85 years; 4. Except other skin diseases of hands and feet; 5. No serious organ dysfunction or autoimmune disease; 6. Able to communicate normally and sign informed consent; 7. The skin local dialectic is characterized by dull sensation and pain in the skin lesion, fixed immobility, crusts, erythema, blisters, erosion and even ulceration, or combined with pus scab and blood scab.
Exclusion criteria
Exclusion criteria: 1. Previous skin diseases or systemic diseases combined with skin lesions; 2. Those currently undergoing treatment for HFSR; 3. Targeted angiogenesis inhibitors have been discontinued or are expected to be discontinued within 2 weeks due to tumor progression; 4. People with allergies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hand-foot skin reaction (HFSR) grading; | — |
Secondary
| Measure | Time frame |
|---|---|
| Dimension of skin lesion;Pain;Quality of life;Tolerance of targeted therapy;Safety; | — |
Countries
China
Contacts
Public ContactPeng Yanmei
Fangshan Hospital Beijing University of Chinese Medicine
Outcome results
None listed