Major depressive disorder (MDD)
Conditions
Interventions
SSRI group:N/A
SNRI group :N/A
Sponsors
Beijing Anding Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
16 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Out-patient, aged 16-65 years; No gender limit; The Han nationality; Right-handed; 2. Meet the diagnostic criteria for major depressive disorder of the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), with either first episode or relapse, without psychotic symptoms; 3. No antidepressant therapy has been taken in the last 14 days of this depressive episode; 4. Primary school education or above, able to understand the content of the scale; 5. No contraindications to MRI scanning such as implantation of electronic and metal instruments; 6. Informed consent signed by the patient.
Exclusion criteria
Exclusion criteria: 1. Current or past DSM-5 compliant diagnoses other than depressive disorders include schizophrenia spectrum and other psychotic disorders, bipolar and related disorders, neurodevelopmental disorders, neurocognitive disorders, disruptive impulse control, and conduct disorders; 2. Currently have substance-related and addictive disorders; 3. Serious organic diseases or history of important systems or organs; 4. Pregnant or lactating patients; 5. The researcher judged poor compliance or inappropriate participation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton Depression Scale (HAMD-17) total score reduction;Neuroimaging feature; | — |
Secondary
| Measure | Time frame |
|---|---|
| Correlation of neuroimaging features with depressive symptoms;Correlations between neuroimaging features and measures such as cognition / social functioning; | — |
Countries
China
Contacts
Public ContactLiu Rui
Beijing Anding Hospital, Capital Medical University
Outcome results
None listed