immune thrombocytopenia
Conditions
Interventions
NC-group:Short-course high-dose glucocorticoids.
CON-group:Short-term high-dose glucocorticoids combined with oseltamivir
Sponsors
Fujian Children's Hospital
Eligibility
Sex/Gender
All
Age
1 Years to 14 Years
Inclusion criteria
Inclusion criteria: 1) Patients met the diagnostic criteria of ITP within 3 months of first diagnosis 2) age > 28 days but =14 years old 3) Poor gamma globulin response: platelet count < 30×109/L after 1 week of intravenous immunoglobulin (IVIG) treatment 4) Informed consent has been signed
Exclusion criteria
Exclusion criteria: 1) Patients with intracranial hemorrhage or severe gastrointestinal or urinary tract bleeding need emergency treatment, such as simultaneous use of platelet transfusion and thrombopoietin (recombinant human thrombopoietin, eltrombopag, etc.) 2) patients received glucocorticoid therapy within 6 months 3) menstruating female children 4) patients with underlying diseases such as neoplastic diseases, autoimmune diseases or genetic diseases 5) patients who had received chemoradiotherapy 6) have contraindications to glucocorticoid use (hypertension, glaucoma, peptic ulcer, etc.) 7) have any significant comorbidity or mental illness that may affect patient safety and compliance, informed consent, study participation, follow-up, or result interpretation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Platelet count;Short-term high-dose glucocorticoids combined with oseltamivir; | — |
Countries
China
Contacts
Public Contacthuangsihan
Fujian Children's Hospital
Outcome results
None listed