the efficacy and safety of cryotherapy combined with intra-articular injection of tranexamic acid in the rehabilitation after total knee arthroplasty

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300071161

Enrollment

Unknown

Registered

2023-05-06

Start date

2017-01-15

Completion date

Unknown

Last updated

2023-06-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

joint survey

Interventions

A group:normal saline

B group:TXA

C group:cold therapy+TXA

Eligibility

Sex/Gender

All

Age

50 Years to 80 Years

Inclusion criteria

Inclusion criteria: Patients with end-stage osteoarthritis of the knee undergoing primary unilateral total knee arthroplasty; ? preoperative hemoglobin > 110g/L, PTL > 100×10^9, PT and TPTT normal; ? patients who agreed to accept the trial and signed an informed consent form

Exclusion criteria

Exclusion criteria: (1) patients with Raynaud's disease, angiitis obliterans, cold allergy, rheumatoid arthritis, or cryoglobulinemia; (2) severe hepatic and renal dysfunction; ? taking anticoagulants such as clopidogrel and aspirin within 1 week before surgery; ? Poor non-compliance, unable to attend the follow-up on time or lost to follow-up

Design outcomes

Primary

Measure	Time frame
postoperative pain ;blood loss volume;circumference difference;	—

Secondary

Measure	Time frame
deep venous thrombosis;average length of stay;	—

Countries

China

Contacts

Public Contactxiao-huang

the People's Hospital of Guangxi Zhuang Autonomous Region

516258670@qq.com+8615977491390

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026