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Effect of precision lung protective ventilation strategy guided by two methods on intraoperative respiratory function and postoperative pulmonary complications in patients undergoing peritoneal thermoperfusion chemotherapy

Effect of precision lung protective ventilation strategy guided by two methods on intraoperative respiratory function and postoperative pulmonary complications in patients undergoing peritoneal thermoperfusion chemotherapy

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300071154
Enrollment
Unknown
Registered
2023-05-06
Start date
2023-06-01
Completion date
Unknown
Last updated
2023-06-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

phymatology

Interventions

A Group:PEEP was titrated by driving pressure
B group:EIT method titrates individual PEEP

Sponsors

Beijing Shijitan Hospital, Capital Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: The patients, aged 18 years, were selected to receive tumor cell reduction combined with intraperitoneal thermoperfusion chemotherapy without gender limitation

Exclusion criteria

Exclusion criteria: ? body mass index (BMI) > 30 kg/m2; ? is suffering from acute or chronic respiratory disease; ? Patients with moderate or large amount of pleural effusion before surgery; ? History of taking ß2 receptor agonists, ipratropium bromide aerosol, glucocorticoids or theophylline and its derivatives within the past 14 days; (5) Patients with implantable cardiac defibrillators, pacemakers and other implants with electrical activity; ? serious cardiopulmonary dysfunction; ? Severe hemodynamic instability, severe cachexia malnutrition.

Design outcomes

Primary

MeasureTime frame
Postoperative pulmonary complications were followed up;average length of stay;

Secondary

MeasureTime frame
TNF-a;IL-6;iPEEP;Respiratory parameters (Ppeak, Pplat, Pmean, Cdyn, PO2, oxygenation index, fractional flow rate, dead cavity rate);Association of iPEEP levels with postoperative pulmonary complications;

Countries

China

Contacts

Public ContactLi Xiao

Beijing Shijitan Hospital, Capital Medical University

lxfn5563368@126.com+86 10 63926501

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026