Observation on analgesia of total knee arthroplasty
Conditions
Interventions
Ropivacaine group:Various concentrations of ropivacaine with 40mL volume
low doses Dexmedetomidine + Ropivacaine group:Various concentrations of ropivacaine and Dexmedetomidine with 40mL volume
high doses Dexmedetomidine + Ropivacaine group:Various concentrations of ropivacaine and Dexmedetomidine with 40mL volume
Sponsors
Affiliated Hospital of Nantong University
Eligibility
Sex/Gender
All
Age
55 Years to 75 Years
Inclusion criteria
Inclusion criteria: Gender is not limited, ASA grade I-III, aged 55-75 years, body mass index (BMI) 20-29kg / ?. Patients with normal intelligence, ability to understand and willing to participate in this study, and willing to sign informed consent.
Exclusion criteria
Exclusion criteria: Patients with severe cardiopulmonary function, liver and kidney dysfunction; Patients with allergic history of related drugs;the patient was not able or willing to cooperate with testing and assessments; Patients with a long history of gastric ulcer and gas-trorrhagia; Patients cannot tolerate a nerve block; Patients with a contraindication for puncture;Patients with a long history of painful diseases; Patients with a history of drug or alcohol dependence; Contraindications for general anaesthesia; Patients with severe cardiopulmonary function, liver and kidney dysfunction; Patients with high blood pressure, diabetes, mental disorders and mental disorders.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| VAS Scoring;EC50 by sequential approach; | — |
Secondary
| Measure | Time frame |
|---|---|
| Demographic data;nerve block-related conditions;Resuscitation situations;Prognosis of the studied patients;Adverse effects; | — |
Countries
China
Contacts
Public ContactZhongLing Xu
Affiliated Hospital of Nantong University
Outcome results
None listed