Rheumatoid arthritis
Conditions
Interventions
Experimental group:Prednisone acetate,Methotrexate,Leflunomide,Yupingfeng cassia branch granules
Control group:Prednisone acetate,Leflunomide,Methotrexate
Sponsors
The First Affiliated Hospital of Yunnan University of Chinese Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) RA patients who meet the 1987 ACR rheumatoid arthritis classification standard and the traditional Chinese medicine standard for waiting diagnosis of cold and dampness arthralgia syndrome; (2) patients currently taking glucocorticoids (prednisone acetate tablets or equivalent dose of hormone, varying dose); (3)DAS28 score =2.6; (4) No gastrointestinal disease in the past 2 months, no antibiotics, gastrointestinal motility drugs or probiotics; (5) Men and women aged 18-65; (6) Volunteer to participate in the study and agree to enter the clinical study, and sign the informed consent.
Exclusion criteria
Exclusion criteria: (1) A history of severe respiratory (including pulmonary interstitial fibrosis), blood circulation, digestive, endocrine, urinary system diseases and malignant tumors before the study; (2) Those who have taken antibiotics, probiotics and prebiotics in the past 2 months; (3) Patients with bleeding prone active gastrointestinal disease and recent history of surgery; (4) Infection that cannot be controlled by antibiotics, serious infection or opportunistic infection history 2 months before the trial; (5) pregnant and lactating women; (6) Patients participating in other clinical trials; (7) Allergic constitution (allergic to Chinese medicine prescriptions, hormones and other experimental drugs); (8) Mental patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hormone reduction;DAS28 score;alpha diversity;beta diversity;relative abundance; | — |
Secondary
| Measure | Time frame |
|---|---|
| Erythrocyte sedimentation;C-reactive protein;Liver function;renal function;Blood routine;Urine routine;Stool routine;TCM syndrome score;adrenocorticotropin;cortisol;Pain VAS scores assessed by patients; | — |
Countries
China
Contacts
Public ContactPeng Jiangyun
Yunnan Hospital of Traditional Chinese Medicine
Outcome results
None listed