Effect of different drug interventions on postoperative nausea and vomiting in patients undergoing laparoscopic myomectomy

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300071104

Enrollment

Unknown

Registered

2023-05-05

Start date

2023-08-24

Completion date

Unknown

Last updated

2023-09-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

postoperative nausea and vomiting

Interventions

A group:Sevoflurane maintenance anesthesia

Granisetron prevents postoperative nausea and vomiting

B group:Sevoflurane maintenance anesthesia

Granisetron combined with dexamethasone to prevent postoperative nausea and vomiting

C group:Propofol to maintain anesthesia

D group:Propofol to maintain anesthesia

Eligibility

Sex/Gender

Female

Age

35 Years to 55 Years

Inclusion criteria

Inclusion criteria: 1. Patients who underwent total laparoscopic hysterectomy for the first time; 2. ASA I to II; 3. Aged 35 to 55; 4. Subjects voluntarily participated in this study and signed the exclusion criteria for informed consent.

Exclusion criteria

Exclusion criteria: 1. Known allergy or prior adverse reactions to any study drug; 2. Laparoscopic lymph node dissection; 3. Severe cardiovascular or pulmonary disease; 4. Body mass index > 35 kg/m2; 5. Vestibular dysfunction; 6. Gastroesophageal reflux; 7. Patients with a history of antiemesis treatment 24 hours before surgery; 8. Patients who received open surgery dropped out of the study.

Design outcomes

Primary

Measure	Time frame
PONV score;VAS score;R-INVR score;Serum MTL concentration;Serum 5-HT3 concentration;	—

Countries

China

Contacts

Public ContactLei Wei

Suzhou Hospital Affiliated to Nanjing Medical University

64624369@qq.com+86 138 1487 4405

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026