cardiac surgery with cardiopulmonary bypass
Conditions
Interventions
the intervention group:Heparin initial dose (500U/Kg)
the control group:Heparin initial dose (400U/Kg)
Sponsors
The First Affiliated Hospital of Wenzhou Medical University
Eligibility
Sex/Gender
Male
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria were applied: (1) signed informed consent; (2) elective cardiac surgery with extracorporeal circulation, including heart valve replacement and coronary artery bypass grafting; (3) age: 18-75 years; (4) normal preoperative coagulation function.
Exclusion criteria
Exclusion criteria: exclusion criteria were applied: 1.urgent operation, 2.reoperation,3. heparin-induced thrombocytopenia, known pre-existing hemolytic disorders, known coagulation system disorders, chronic inflammatory disease, 4. ongoing Antiplatelet or anticoagulant treatment other than aspirin,5.Heparin allergy, heparin resistance,6.with NYHA IV cardiac function
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Syndecan-1?HS, HPSE activity; | — |
Secondary
| Measure | Time frame |
|---|---|
| IL-6,TNF-a, ostoperative blood loss 24h, total postoperative blood loss,extubation time after operation, length of hospital stay, and other systemic complications; | — |
Countries
china
Contacts
Public ContactWeijian Wang
The First Affiliated Hospital of Wenzhou Medical University
Outcome results
None listed