Evaluation of the clinical and growth-related significance of probiotics in preterm infants

Evaluating the effects of probiotics in pre-term infants: an interventional contribution to meet child health related sustainable development goals

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2300071089

Enrollment

Unknown

Registered

2023-05-04

Start date

2023-05-15

Completion date

Unknown

Last updated

2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Preterm birth complications

Interventions

Placebo/1:Dextrose water 10%

Single Strain/2:Lactobacillus rhamnosus (Prepro GG)

Multistrain/3:Bifidobacterium BB-12, Lactobacillus paracasei, L casei-431, Streptococcus thermophilus TH-4 (Amybact)

Eligibility

Sex/Gender

All

Inclusion criteria

Inclusion criteria: 1. Male and female preterm neonates admitted to NICU of Bahawal Victoria Hospital; 2. Gestational age of < 37 weeks; Weight at birth < 2,500 g; 3. Readiness to commence on feeds; 4. Informed parental consent.

Exclusion criteria

Exclusion criteria: 1. Congenital malformations; 2. Chromosomal aberrations; 3. Not being ready for feeds; 4. Early onset sepsis (C-reactive protein (CRP) > 10 mg/L in the first 72 h of life); 5. Neonates with major gastro-intestinal abnormalities or requiring surgery of the gastro-intestinal tract.

Design outcomes

Primary

Measure	Time frame
Mortality;Necrotizing Enterocolitis;	—

Secondary

Measure	Time frame
Sepsis;Intracerebral hemorrhage and periventricular leukomalacia ;Retinopathy of prematurity;Bronchopulmonary dysplasia;Growth;Feeding pattern;	—

Countries

Pakistan

Contacts

Public ContactDr. Imran Masood

The Islamia University of Bahawalpur

drimranmasood@iub.edu.pk+92 314 6266253

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: May 1, 2026