the breakthrough pain of labor analgesia
Conditions
Interventions
group R:When breakthrough pain occurrs, 6 mL of 0.125% ropivacaine was given by epidural bolus.
group C1:In case of breakthrough pain, 6 mL 0.5% cloprocaine was given by epidural bolus.
group C2:In case of breakthrough pain, 6 mL 1.0% cloprocaine was given by epidural bolus.
group C3:In case of breakthrough pain, 6 mL 1.5% cloprocaine was given by epidural bolus.
Sponsors
Anhui Province Maternity and Child Health Hospital
Eligibility
Sex/Gender
Female
Age
20 Years to 36 Years
Inclusion criteria
Inclusion criteria: 1. After epidural labor analgesia,women who have breakthrough pain; 2. Full term(37 to 41 weeks gestation); 3. Singleton; 4. Aged 20~36 years; 5. BMI 21.0-35.0 kg/m2; 6. American Society of Anesthesiologists physical status II or III.
Exclusion criteria
Exclusion criteria: 1. Contraindications of intraspinal anesthesia; 2. Cephalopelvic disproportion; 3. Abnormal birth canal conditions; 4. Severe pregnancy complications; 5. Fetal malformation or stillbirth; 6. History of chronic pain; 7. History of prenatal use of analgesic, sedative and hypnotic drugs; 8. Mental illness, cognitive dysfunction; 9. Allergic history to opioids, procaine and other esters and amides; 10. Delivery within 1 hour after epidural analgesia.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The success rate of treatment of breakthrough pain;Time of onset of investigational drugs to suppress breakthrought pain; | — |
Secondary
| Measure | Time frame |
|---|---|
| Visual Analogue Scale (VAS) score at different time points;Improved Bromage score at different time points;Interval and duration of the first 12 contractions after administration;Number of breakthrough pain;Maternal satisfaction;level of anesthesia;The amount of study drug used to suppress breakthrough pain;Dosage of analgesic pump drugs;The time of the first breakthrough pain;Cervical orifice size at the time of the first breakthrough pain;The salvage treatment rate of 1% lidocaine;Interval between the onset of each two breakthrough pain intervals between each two breakthrough pain;Delivery situation;Neonatal outcome;Incidence of adverse reactions; | — |
Countries
China
Contacts
Public ContactHaijuan Zhu, Tianzhen Ji
Anhui Province Maternity and Child Health Hospital
Outcome results
None listed