Urolithiasis
Conditions
Interventions
Low potential renal acid load(PRAL) diet:Low potential renal acid load (PRAL) diet: limit animal protein, increase vegetable and fruit intake, increase fluid intake. The low PRAL value is based on the
The Potassium Citrate group:Oral potassium citrate sustained-release tablets 2 tablets, twice a day, and usual diet.
The usual diet group:Usual diet (control group)
Sponsors
The Second Affiliated Hospital of Kunming Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: • Patients more than18 years old less than 60years old. • Recurrent urolithiasis patients, based on having a history of at least 2 episodes of stone formation diagnosed. (The stone formation was a twice new diagnosed kidney stone by urologist) • The stone composition confirmed as calcium oxalate. • Oral diet capability. • Not participating in other clinical research.
Exclusion criteria
Exclusion criteria: • Documented stone analysis with any calcium carbonate, magnesium ammonium phosphate, and calcium phosphate composition. • Systemic cause for stone disease (primary hyperparathyroidism, complete distal renal tubular acidosis, systemic acidosis, active urinary tract infection). • Concurrent medication therapy (potassium citrate, sodium citrate, sodium bicarbonate, diuretic, angiotensin-converting enzyme inhibitor, angiotensin II receptor antagonist, topiramate, acetazolamide). • Renal insufficiency (GFR <50ml/min/m2). • Elevated serum potassium level (= 4.5 mmol/L) or hyperkalemia. • Pregnancy. • Morbidity: gout, hyperuricemia, chronic diarrhea, insulin resistance, hyperparathyroidism, idiopathic hypercalcemia, hypertension, diabetes mellitus. • Complicated with infection, with or without antibiotic treatment. • Patients with active urinary tract infection • Previous gastrointestinal diseases or gastrointestinal surgery. • Mental patients or unable to cooperate for various reasons. • Patients with peptic ulcer disease. • Postoperative severe urinary infection or severe urinary infection. • Postoperative symptomatic patients. • Can not eat low PRAL diet. • Inability to obtain informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 24-hour urine solute analysis (urine citric acid, urine potassium, uric oxalic acid, urine calcium, uric acid); | — |
Countries
China
Contacts
Public ContactPei Li
The Second Affiliated Hospital of Kunming Medical University
Outcome results
None listed