postoperative delirium
Conditions
Interventions
S-ketamine group:At the beginning of the operation, the patients were infused with ketamine 0.5 mg/kg · h continuously until the surgeon began to suture the skin.
Control Group:At the beginning of the operation, the patients were infused with the same volume of saline as S-ketamine Group continuously until the surgeon began to suture the skin.
Sponsors
The Second Affiliated Hospital of Shandong First Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. American Society of Anesthesiologists (ASA) physical status classification I–III. 2.Undergoing breast surgery. 3.Voluntary participation in the trial and signed informed consent.
Exclusion criteria
Exclusion criteria: 1.History of severe psychiatric disease. 2.History of glaucoma or hyperthyroidism. 3.History of severe hepatic (Child-Pugh grade C) or renal (requirement for renal replacement therapy) disorders. 4.Body mass index (BMI) ?35 kg/m². 5. Dementia history or baseline Mini-Mental State Examination (MMSE) score of 200/110 mm Hg). 9. Allergic to dexmedetomidine or S-ketamine. 10. Taking sedatives, antidepressants or glucocorticoids. 11. Alcohol or illicit drug misuse disorder. 12. Life expectancy of less than 2 months due to extensive tumor metastasis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| postoperative delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| postoperative pain;the subtype, severity and duration of POD; | — |
Countries
China
Contacts
Public ContactLimin Zhou
The Second Affiliated Hospital of Shandong First Medical University
Outcome results
None listed