acute pancreatitis complicated by Gram-positive bacterial infection
Conditions
Interventions
None:Contizolamide tablets are taken orally at 800mg (2 tablets) every 12 hours* 7or 14 days
Sponsors
Sir Run Run Shaw Hospital Affiliated to Zhejiang University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1: Age =18 and less than or equal to 70 2: Patients were diagnosed with acute pancreatitis according to Chinese Guidelines for Diagnosis and Treatment of Acute Pancreatitis (2021). The diagnostic criteria for acute pancreatitis include the following 3 criteria: (1) persistent pain in the upper abdomen 3: (2) serum amylase and/or lipase concentrations were 3 times higher than the normal upper limit 4: (3) Abdominal imaging examination results showed imaging changes consistent with acute pancreatitis. Acute pancreatitis is diagnosed if two of the three criteria are met 5: Patients with pancreatic (peripancreatic) or extrapancreatic infections (such as biliary system, lung, urinary system, catheter associated infections) caused by clinical microbiology diagnosis or clinical suspicion of gram-positive bacteria 6: After percutaneous drainage, surgical video-assisted debridement or laparotomy, patients with abdominal or retroperitoneal effusion or peripancreatic exudation can be collected by drainage. And/or, cholecystostomy or choledochal drainage may be performed in patients for whom bile can be collected 7: Volunteer to participate in the study and sign the informed consent. If the subject is unable to read and sign the informed consent due to incapacity or other reasons, his/her guardian shall represent the informed process and sign the informed consent. If the subject does not have the ability to read the informed consent (such as illiterate subjects), a witness shall witness the informed process and sign the informed consent
Exclusion criteria
Exclusion criteria: 1: Allergic to oxazolidinones 2: Those who are not suitable for administration through nasal feeding/gastrointestinal nutrition tube, or with gastrointestinal diseases that seriously affect oral drug absorption 3: According to AGI classification, gastrointestinal function evaluation is grade IV 4: Prior to 3 months to participate in other clinical study patients 5: Participants considered unfit to participate in the study or to influence the evaluation of the end points for a variety of reasons, such as pregnant and lactating women, or men or women who were unable to use effective contraception during the study period or within 6 months of the end of the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Clinical cure rate; bacterial clearance rate; | — |
Countries
CHINA
Contacts
Public ContactYU HONG
Sir Run Run Shaw Hospital Affiliated to Zhejiang University School of Medicine
Outcome results
None listed