Post-stroke depression
Conditions
Interventions
The Control Group :Placebo
The Experimental Group:Shuganjieyujiaonang
Sponsors
Tongji Medical College of Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Aged 18 to 75 years old, males or females. 2.Ischemic stroke confirmed by computed tomography (CT) or magnetic resonance imaging (MRI). 3.Meeting the Diagnostic and Statistical Manual of Mental Disorders - Fifth Edition (DSM-V) diagnostic criteria for post-stroke depression (PSD) (duration of symptoms = 2 weeks). 4.18 = HAMD-17 score = 24 before treatment. 5.Signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Brain dysfunction caused by other non-vascular causes (such as primary brain tumors, brain metastases, subdural hematoma, post-seizure paralysis, brain trauma, etc.). 2. Previous history of depression, dementia and mental illness; Previous antidepressant treatment. 3. Impaired vision, hearing, speech expression, consciousness and comprehension (MMSE1.5 times the upper limit of normal. 8. Patients with renal insufficiency (eGFR 11 × 109 /L) 10. Severe diseases such as rheumatism, rheumatoid disease, vasculitis and tumor 11.PSD with psychiatric symptoms or severe PSD with suicide risk. 12. Patients with bipolar disorder were found during follow-up. 13. Patients assessed by the investigator as unsuitable for inclusion or unable to complete the interview. 14. Those who have taken Shuganjieyu Capsules in the past 1 month; Patients with serious adverse reactions to Shuganjieyu Capsule.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HAMD-17; | — |
Secondary
| Measure | Time frame |
|---|---|
| HAMA;NIHSS;BI;mRS;MMSE;SDS;PARS-3;FSS;ESS;ISI;GAD-7;PHQ-9;PHQ-15;PDQ-D-20;PSQI;SS-QOL;EPQ; | — |
Countries
China
Contacts
Public ContactZhu Suiqiang
Department of Neurology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed