MDD
Conditions
Interventions
Test group:A group of subjects received the "psychotherapy" intervention and the "anterior cingulate gyrus functional connectivity positioning" intervention, respectively, using an ABBA design to bala
Sponsors
The Affiliated Hospital of Hangzhou Normal University
Eligibility
Sex/Gender
All
Age
12 Years to 18 Years
Inclusion criteria
Inclusion criteria: (1)HAMD-17 > 17 points; (2)Meet the diagnostic criteria for depression in the International Classification of Diseases DSM-V, and be diagnosed with depression or bipolar disorder; (3)The current depressive episode was confirmed by the questionnaire of Emotional Disorders and schizophrenia in school-age children, KidDI-SADS Lifetime Edition (K-SADS-PL); (4)No gender limitation, age 12-18 years; (5)Subjects who are able to understand and willing to strictly follow the clinical trial protocol to complete the study, have informed consent from the guardian and can sign informed consent.
Exclusion criteria
Exclusion criteria: (1) Contraindicated patients with MRI and TMS; (2)Severe physical and neurological disorders; (3)Schizophrenia, history of abuse of tobacco, alcohol and other psychoactive substances; (4)The patient is a pregnant or lactating woman or planning to become pregnant; (5)No immunomodulators and hormone preparations for at least half a year, no antipyretic and analgesic drugs for 2 weeks; (6) Those considered unsuitable for inclusion by researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton Depression Scale, HAMD;Hamilton Anxiety Scale, HAMA;Theamplitudeof low-frequency fluctuations, ALFF;Functional connection, FC;reagional homogeneity, ReHo; | — |
Secondary
| Measure | Time frame |
|---|---|
| Snaith-Hamilton Pleasure Scale, SHAPS;Mood Disorder Questionnaire, MDQ;The Insomnia Severity index, ISI;Self-rating depression scale, SDS;the 21-item Depression Anxiety Stress Scale, DASS-21;Beck Scale for Suicide Ideation-Chinese Version, BSI- CV;Visual Analogue Score, VAS; | — |
Countries
China
Contacts
Public ContactZang Yufeng
Hangzhou Normal University
Outcome results
None listed