Hypertrophic Cardiomyopathy(HCM)
Conditions
Interventions
Patients with transapical beating-heart septal myectomy:N/A
Sponsors
Department of Ultrasound Imaging, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Age ?18 years old; 2.Patients who were diagnosed as hypertrophic obstructive cardiomyopathy (HOCM) with mitral regurgitation (MR) ?2+ and underwent transcapical septal resection (TA-BSM) were enrolled; 3.The maximum thickness of interventricular septum =15mm; 4.LVOTG=50mmHg measured by transthoracic echocardiography in resting state or stimulated state; 5.Obvious clinical symptoms, poor effect after adequate drug treatment or unable to tolerate adverse drug reactions; 6.New York Heart Association (NYHA) functional class =II; 7.Voluntary informed consent.
Exclusion criteria
Exclusion criteria: 1.Non-obstructive hypertrophic cardiomyopathy; 2.Complicated with other cardiac diseases requiring surgical treatment (e.g., coronary artery surgery); 3.Patients with previous history of mitral valve surgery, aortic valve surgery, previous ventricular septal resection; 4.Organic mitral valve structural abnormality; 5.Heart failure, left ventricular ejection fraction <40%; 6.Pregnant and lactating patients; 7.Patients with life expectancy less than 12 months; 8.Patients have participated in other drug/medical device clinical trials within 3 months; 9.Severe liver failure 10.Cerebrovascular accident within 3 months; 11.Acute gastrointestinal ulcer or upper gastrointestinal bleeding within 3 months; 12.The researchers judged that the subjects had poor compliance and could not complete the study according to the requirements. 13.Are receiving other treatments that may affect cardiac function (e.g., adjuvant radiotherapy, chemotherapy); 14.Patients with poor echocardiographic image quality;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Effective regurgitant orifice area(EROA,cm2);Regurgitant volume(RVol,ml);Regurgitant fraction(RF,%);Left ventricular outflow tract pressure difference(LVOTG,mmHg); | — |
Secondary
| Measure | Time frame |
|---|---|
| Anterior mitral valve length(AML,mm);Posterior mitral valve length(PML,mm);Mitral annular area(mm2);Annulus circumference of mitral valve(Annulus Perimeter,mm);Anteroposterior diameter of mitral annulus(A-P Diameter,mm);Mitral annular commissure diameter(mm);Mitral annular height(mm);Mitral tenting height(mm);Mitral tenting volume(ml);Aortomitral angle (°);Area of the anterior leaflet of the mitral valve,mm2;Area of the posterior mitral leaflet,mm2;Mitral valve coaptation height,mm;Residual length of the anterior mitral leaflet; | — |
Countries
China
Contacts
Public ContactYani Liu
Department of Medical Ultrasound, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Outcome results
None listed