vitamin K2 deficiency and Bone Metabolism Abnormal
Conditions
Interventions
Women during pregnancy:None
Sponsors
Peking Union Medical College Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. Serum 25(OH)D = 20ng/ml 2. Biological samples are complete and properly preserved, without hemolysis or repeated freezing and thawing 3. Eating behavior and mental health are normal 4. Can obtain complete clinical data during pregnancy
Exclusion criteria
Exclusion criteria: 1. History of digestive system diseases and surgery 2. Blood system or immune system disease 3. Pre-gestational diabetes, high blood pressure 4. Taking anticoagulant drugs (such as warfarin, aspirin, heparin) or vitamin K fortified supplements exceeding dietary recommendations
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Vitamin K2;Vitamin K1;amino-terminal propeptide of type?procollagen;C-telopeptide crosslink;uncarboxylated matrix gamma-carboxyglutamic acid protein;vascular endothelial growth factor;placental growth factor;soluble fms-like tyrosine kinase 1;uncarboxylated osteocalcin/ osteocalcin; | — |
Secondary
| Measure | Time frame |
|---|---|
| pregnancy outcome; | — |
Countries
China
Contacts
Public ContactLiu Yan-ping
Peking Union Medical College Hospital
Outcome results
None listed