Infertile women with advanced maternal age
Conditions
Interventions
controlled group:standard IVF treatment
experimental group:standard IVF treatment with growth hormone co-treatment
Sponsors
Peking University People's Hospital
Eligibility
Sex/Gender
Female
Age
35 Years to 45 Years
Inclusion criteria
Inclusion criteria: (1) women of advanced maternal age: =35 and <45 to be specific (2) women without growth hormone treatment within 3 months (3) women with less than 2 previous COH cycles or embryo transfer cycles (4) 18.5kg/m2=BMI=30kg/m2 (5) women who participate voluntarily with written consent
Exclusion criteria
Exclusion criteria: (1) women with present abnormalities of uterus: adenomyosis, submucous myoma or intramural myoma affecting the uterine cavity, genital malformation, endometrial polyp, uterine cavity adhesion, thin endometrium, etc (2) women with other present gynecological disease: tuberculosis of the reproductive system, ovarian cyst, untreated severe hydrosalpinx, etc (3) patients with PGT indications, including: paternal or maternal chromosome abnormality, RIF, RSA, monogenetic disease, etc (4) patients undergoing ICSI cycle for the following reason: azoospermia or severe oligozoospermia (WHO 5th edition standard), PESA, TESA (5) patients with growth hormone contradictions, including: diabetes, severe systematic infections, cancer with active state, intracranial injury, pregnancy, etc (6) systematic disease: thyroid disease, diabetes, adrenal gland abnormality, and other chronic disease without control/treatment, etc (7) disease not suitable for pregnancy (8) known immmune diseases leading to infertility (9) previous 2 consecutive ICSI cycles with ferterlization rate <50%
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ongoing pregnancy; | — |
Secondary
| Measure | Time frame |
|---|---|
| live birth rate;implantation rate;chemical pregnancy rate;early miscarriage rate;cumulative live birth rate;No. of MII oocytes;ferilization rate;No. of good quality embryos;Endometrium thickness on trigger day; | — |
Countries
China
Contacts
Public ContactHan Hongjing
Peking University People's Hospital
Outcome results
None listed