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Gut microbiota Prevotella regulate FRZB/Wnt signaling pathway through SCFAs to induce the injury of chondrocyte in Kashin-Beck disease

Gut microbiota Prevotella regulate FRZB/Wnt signaling pathway through SCFAs to induce the injury of chondrocyte in Kashin-Beck disease

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2300070898
Enrollment
Unknown
Registered
2023-04-26
Start date
2023-01-01
Completion date
Unknown
Last updated
2023-06-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Kashin-Beck disease and Osteoarthritis

Interventions

osteoarthritis:N/A
normal controls:N/A
Kashin-Beck disease:N/A

Sponsors

Xi'an Jiaotong University Honghui hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
50 Years to 85 Years

Inclusion criteria

Inclusion criteria: (1) Confirmed patients with osteoarthritis and diagnosed patients with Kashin-Beck disease (2) Age 50-85

Exclusion criteria

Exclusion criteria: (1) Pregnant women: It is not suitable for both healthy and Kashin-Beck disease patients to participate; (2) Those who cannot undergo radiation testing due to special reasons; (3) Patients with rheumatoid arthritis, rheumatoid arthritis, and other bone or cartilage diseases; (4) Resident population in non ward areas (residing for less than 6 months); (5) The population participating in other research projects that may interfere with the results of this study; (6) Those who cannot receive blood sample collection. (7) Those who have any other questions about this study and have not received a satisfactory response

Design outcomes

Primary

MeasureTime frame
Abundance value of gut microbiota;—

Countries

China

Contacts

Public ContactZhao Hongmou

Xi'an Jiaotong University Honghui hospital

zhao_hongmou@hotmail.com+86 13759713520

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026