postoperative sore throat
Conditions
Interventions
Dexmedetomidine combined with lidocaine group:Before intubation, 2% lidocaine 1ml + dextromethorphan 2ml (0.5 UG * body weight) was sprayed into the larynx of anesthesia tube
Lidocaine group:Before intubation, 3 ml of 2% lidocaine was sprayed into the larynx of anesthesia tube
Saline Group:Before intubation, 3ml normal saline was sprayed into the throat of the jugular anesthesia tube
Sponsors
The First Affiliated Hospital of Anhui Medical University
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Female patients; 2. Aged 18-65; 3. With normal communication; 4. Signed informed consent; 5. Were scheduled to undergo thyroidectomy under general anesthesia.
Exclusion criteria
Exclusion criteria: 1. History of allergic reaction to local anesthetics; 2. Severe heart disease, liver and kidney dysfunction; 3. Airway difficulty or history of maxillofacial and neck surgery; 4. Patients with chronic respiratory diseases (such as chronic obstructive pulmonary disease or asthma), recent respiratory tract infection, chronic cough and current smoking; 5. Serious adverse events, such as bleeding, who underwent reoperation for more than 4 hours; 6. Time of anesthesia for more than 4 hours; 7.For delayed extubation (more than 1 hour without extubation) due to adverse effects of experimental drugs, and were transferred to Intensive Care Unit (ICU) with tube.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cough in the waking period; | — |
Secondary
| Measure | Time frame |
|---|---|
| postoperative sore throat;Postoperative nausea and vomiting;Postoperative hoarseness; | — |
Countries
China
Contacts
Public ContactChen Lijian
Department of Anesthesiology, the First Affiliated Hospital of Anhui Medical University
Outcome results
None listed