chronic ocular graft-versus-host disease
Conditions
Interventions
allo HSCT:None
Sponsors
The Second Affiliated Hospital of Army Medical University
Eligibility
Sex/Gender
All
Age
6 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Age range from 6 to 80 years old, regardless of gender; (2) Blood disease patients who require allogeneic hematopoietic stem cell transplantation (allo HSCT); (3) Obtain informed consent from patients and their families, and voluntarily sign an informed consent form.
Exclusion criteria
Exclusion criteria: (1) Meeting the diagnostic criteria for dry eyes (refer to the 2020 consensus of Chinese dry eye experts): The patient complained of one of the subjective symptoms such as dry eye sensation, foreign body sensation, burning sensation, fatigue, discomfort, redness of the eye, visual fluctuation, etc., with an ocular surface disease index (OSDI) of >= 13 points, while the patient's FBUT 5 seconds and 5 mm/5 minutes and <= 10mm/5 minutes, the keratoconjunctiva must be examined using fluorescein sodium staining method, and the staining is positive (= 5 points). (2) People with acute eye diseases such as active fungal, bacterial, or viral keratitis or conjunctivitis; (3) Individuals with other chronic eye diseases unrelated to chronic graft versus host disease, such as lacrimal duct disease, uveitis, glaucoma, etc. (4) Wearing contact lenses and unwilling to remove them during the study period; (5) Have undergone eye surgery (including cataract surgery) within the past three months; (6) Unable to cooperate in completing the research as requested by the researcher; (7) Any other situation that the researcher deems unsuitable for inclusion in the study;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| OSDI;Schirmer?test;FBUT;NIKBUT;Eye surface comprehensive analyzer;In vivo confocal microscopy;Optical coherence tomography angiography;Tear cytokine detection; | — |
Secondary
| Measure | Time frame |
|---|---|
| Best corrected vision;Non contact intraocular pressure;Corneal endothelial cell count; | — |
Countries
China
Contacts
Public ContactRongdi Yuan
The Second Affiliated Hospital of PLA Army Medical University
Outcome results
None listed