Intracranial atherosclerotic disease (ICAS)
Conditions
Interventions
Case series:none
Sponsors
General Hospital of Eastern Theater Command
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1) Age 18 to 85 years old; 2) First ischemic stroke or TIA attack; 3) Symptomatic intracranial artery stenosis of 50%-99%, and the responsible blood vessels confirmed by imaging are the intracranial segment of the internal carotid artery, the middle cerebral artery, the intracranial segment of the vertebral artery or the basilar artery; 4) There is at least one atherosclerosis risk factor (such as hypertension, diabetes, hyperlipidemia, etc.); 5) The time from the onset of this symptom to hospitalization = 3 weeks; 6) The Modified Rankin Scale (mRS) score before the index event = 2 points; 7) Sign a written informed consent form.
Exclusion criteria
Exclusion criteria: 1) Severe cognitive decline (Mini-mental State Examination (MMSE) score>24) or preexisting dementia or Parkinson's disease; 2) Intracranial hemorrhage, epidural or subdural hemorrhage confirmed by CT or MRI; 3) History of cerebrovascular intervention therapy and surgical procedures; 4) Existence of other vascular diseases: arterial dissection, Moyamoya, aneurysm, arteriovenous malformation, etc; 5) Medical conditions that affect brain structure or function (such as head trauma, hydrocephalus, intracranial tumors, major mental illness, multiple sclerosis, encephalitis, depression, poisoning, etc.); 6) Contraindications to MRI scanning (such as claustrophobia, metal implants in the body such as pacemakers, etc.); 7) Individuals with severe hearing or visual impairment who are unable to undergo cognitive function testing; 8) Participate in drug trials; 9) Expected survival time<1 year; 10) During the follow-up period, received intracranial arterial intervention treatment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ischemic stroke; | — |
Secondary
| Measure | Time frame |
|---|---|
| Post-stroke cognitive impairment;Any stroke (ischemic or hemorrhagic) event;Any stroke, TIA, death, or cardiovascular event;Changes in cerebral perfusion;Changes of characteristics of atherosclerotic plaque in arteries;Changes in brain tissue structure;Changes in neurological function and daily living ability scores (NIHSS score, mRS score, and Barthel index) compared to baseline scores during follow-up; | — |
Countries
China
Contacts
Public ContactDu Juan
General Hospital of Eastern Theater Command
Outcome results
None listed