Parkinson's disease
Conditions
Interventions
Classic positioning group :Using P3 and P4 points as stimulation targets in the 10-20 system
precision positioning group:Using the point with the strongest fMRI activation in the exercise imagination task as the stimulation target for TMS
Sponsors
The Affiliated Hospital of Hangzhou Normal University
Eligibility
Sex/Gender
All
Age
40 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Sporadic PD patients meeting the diagnostic criteria of MDS who had experienced at least one frozen gait in the last 1 month; (2) Age 40-75 years old; (3) During the study period, anti-Parkinson's drugs were not adjusted (drug optimization and adjustment were conducted before the study); (4) Hoehn-Yahr stages 2-4; (5) Exercise imagination, KVIQ score >= 3 points; (6) MMSE score >= 26 points; (7) No lower limb injury, no MRI contraindications; (8) No stereotactic surgery was performed; (9) No other neurological disease or mental illness.
Exclusion criteria
Exclusion criteria: (1) secondary Parkinson's disease or Parkinsonism-plus syndrome; (2) severe heart, liver and kidney insufficiency; (3) after deep brain stimulation or other nerve implantation; (4) A history of seizures; (5) Mental and psychological abnormalities, unable to cooperate with MRI scanning and TMS intervention.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the activity of PPC region; | — |
Secondary
| Measure | Time frame |
|---|---|
| UPDRS-III;nFOGQ;TUG test;10MWT; | — |
Countries
China
Contacts
Public ContactHu Zhengxiang
The Affiliated Hospital of Hangzhou Normal University
Outcome results
None listed