gouty nephropathy
Conditions
Interventions
Experimental group:Oral administration of febuxostat tablets and Jianpi Xiaoshi granules
Control group:Oral febuxostat tablets
Sponsors
The First Affiliated Hospital of Yunnan University of Chinese Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: (1) Those who meet the diagnostic criteria of gouty nephropathy in Western medicine and syndrome differentiation criteria of spleen deficiency and dampness in Chinese medicine; (2) The age range was 18 to 70 years old, and the gender was not limited; (3) Informed consent and voluntary participation in the treatment; (4) The serum creatinine value of patients with abnormal renal function was more than 104umol/L, but less than 177umol/L (renal function compensation period).
Exclusion criteria
Exclusion criteria: (1) Those who were in the acute phase of gouty arthritis at the time of screening; (2) Patients with elevated blood uric acid due to previous history of renal disease or renal insufficiency; (3) Patients with elevated blood uric acid caused by secondary nephropathy caused by hematological system, severe psoriasis, widespread spread of malignant tumors, or damage caused by radiotherapy and chemotherapy; (4) Suffering from serious diseases of other organs or systems, such as cardiovascular and cerebrovascular diseases, lung and liver diseases; Or suffers from a serious disease that affects their survival, such as AIDS; (5) Allergic constitution, drug allergy involved in this study; (6) Special groups: women during pregnancy or breastfeeding, or those suffering from mental diseases; (7) Additional lesions or conditions that may complicate enrollment, as determined by the investigator; (8) A history of alcohol or drug abuse; (9) Patients who are participating in clinical trials of other drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Estimate glomerular filtration rate;Degree of improvement in serum creatinine (SCr);liver function; | — |
Secondary
| Measure | Time frame |
|---|---|
| routine urine test;Blood uric acid compliance rate;Number of acute arthritis episodes during treatment; | — |
Countries
China
Contacts
Public ContactLi Zhaofu
Yunnan University of Traditional Chinese Medicine
Outcome results
None listed