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Research on personalized neural modulation method in active rehabilitation training

Research on personalized neural modulation method in active rehabilitation training

Status
Recruiting
Phases
Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300070848
Enrollment
Unknown
Registered
2023-04-24
Start date
2022-12-06
Completion date
Unknown
Last updated
2023-06-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Stroke

Interventions

1:High-frequency repetitive transcranial magnetic stimulation (rTMS) was used to stimulate the ipsilateral sensorimotor cortex, and 30min upper limb rehabilitation training was performed immediately a
2:The contralateral sensorimotor cortex was stimulated by low-frequency rTMS, and 30min upper limb rehabilitation training was performed immediately after stimulation.
3:The ipsilateral sensorimotor cortex was sham stimulated by rTMS, and 30min upper limb rehabilitation training was performed immediately after stimulation
4:The ipsilateral sensorimotor cortex was stimulated by low-frequency rTMS, and 30min upper limb rehabilitation training was performed immediately after stimulation.

Sponsors

Tsinghua University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1) Cerebral infarction patients with initial onset of middle artery injury diagnosed by magnetic resonance imaging, accompanied by motor dysfunction; 2) 0-6 months after the onset of the disease, the patient's condition is stable, without spasm; 3) patients aged between 18 and 80; 4) Clearly aware and able to understand the commands of rehabilitation physicians.

Exclusion criteria

Exclusion criteria: 1) Aphasia, severe cognitive impairment, severe depression, etc.; 2) Unstable condition, including postural hypotension, sepsis, epilepsy, etc.; 3) For patients with upper limb spasm, the Ashworth spasm degree of shoulder, elbow or wrist of the affected limb is greater than grade 2; 4) Dysfunction or failure of heart, lung, liver, kidney and other important organs; 5) Wearing a pacemaker, having metal implants in the skull, or having skull defects; 6) Severe cervical spondylosis including severe cervical canal stenosis and cervical instability.

Design outcomes

Primary

MeasureTime frame
Fugl-Meyer Assessment;

Secondary

MeasureTime frame
EEG;EMG;

Countries

China

Contacts

Public ContactTianyu Jia

Tsinghua University

jiatianyu@mail.tsinghua.edu.cn+86 18813048642

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026