Rheumatoid arthritis
Conditions
Interventions
Control group:MTX,Folic acid tablet
Treatment group:Buzhong Guizhi Zhibi Decoction, MTX, Folic acid tablet
Sponsors
Yunnan Hospital of Traditional Chinese Medicine / The No.1 Affiliated Hospital of Yunnan University of Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Consistent with Western diagnostic standards for rheumatoid arthritis; 2. RA patients who meet the criteria for TCM syndrome of Qi and blood deficiency; 3. Rheumatoid arthritis disease activity criteria were met (DAS28<=3.2); 4. Aged between 18 and 75 years old (regardless of gender, including 18 and 75 years old); 5. The patient knows and voluntarily participates in the clinical study, agrees to sign the informed consent to enter the clinical study, and can actively cooperate with the doctor for treatment,observation and follow-up. Note: According to the above criteria, patients can be excluded if they cannot meet 1 of the criteria.
Exclusion criteria
Exclusion criteria: 1. History of severe respiratory, blood circulation, digestive tract, endocrine, urinary system diseases and malignant tumors before participating in the experiment; 2. Participants are participating in other drug clinical trials,or the drug clinical trial group is less than 1 week; 3. Patients who fail to complete drug treatment as prescribed by the doctor, cannot judge the efficacy, have poor compliance, or have incomplete data; 4. Allergic to experimental drugs; 5. During screening,abnormalities were found in relevant laboratory indicators,such as Cr exceeding 1.5 times the upper limit of normal value, ALT or AST>=2 times the upper limit of normal value; 6. Pregnant, lactating or expectant women; 7. History of neuropsychiatric disorders (epilepsy, depression, etc.); 8. Suspected or existing history of alcohol or drug abuse,or other medical conditions that reduce or compli- cate enrollment, such as frequent changes in the work environment, may cause loss of follow-up. Note: Patients with any one of the above criteria can be excluded.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| erythrocyte;hemoglobin;Classification of rheumatoid factors;CCP;ESR;CRP;Number of joint tenderness;Number of joint swelling;DAS28 score;TCM syndrome score;Evaluation of patient pain (rest pain);Doctor's evaluation of patient's joint pain;electrocardiogram;Chest CT; | — |
Secondary
| Measure | Time frame |
|---|---|
| Liver function;renal function;Urine routine;Fecal routine and occult blood; | — |
Countries
China
Contacts
Public ContactChen YanLin
Yunnan Hospital of Traditional Chinese Medicine / The No.1 Affiliated Hospital of Yunnan University of Chinese Medicine
Outcome results
None listed