perioperative neurocognitive disorders
Conditions
Interventions
POD/DNR group:No intervention
NPOD/NDNR group:No intervention
Sponsors
The Third hospital of Hebei Medical University
Eligibility
Sex/Gender
All
Age
60 Years to 90 Years
Inclusion criteria
Inclusion criteria: (1) Elective orthopedic surgery under combined anesthesia; (2) age >=60 years old and <=90 years old, both sexes; (3) ASA grade ?-?; (4) BMI 18-30 kg/m2; (5) Communication is normal; (6) Informed consent of patients and their families.
Exclusion criteria
Exclusion criteria: (1) The patients with cognitive impairment by mini-mental State examination (MMSE) score less than 24; (2) The patients with brain disease or a history of brain disease(Patients with a definite clinical diagnosis); (3) The patients had a history of neurological and psychological diseases including AD, stroke, psychosis, etc. (4) The patients with long-term use of sedatives, psychotropic drugs, anticholinergic drugs, and anti-inflammatory drugs; (5) The patients with severe hearing or vision impairment; (6) The patients had preoperative systolic blood pressure >190mmhg, or diastolic blood pressure >100mmhg.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| neuropsychological test;MMSE scores;Physical activity scale for the elderly(PASE);Clusterin;Autonomic Nerve Test;Heart Rate Variability(HRV);glycosylphosphatidy linositol specific phospholipase D1(GPLD1);Inflammatory Factor;S100ß;Visual Analogue Scale(VAS);confusion assessment method;Memorial Delirium Assessment Scale;norepinephrine;acetyl choline (ACH);cholinesterase; | — |
Secondary
| Measure | Time frame |
|---|---|
| Geriatric Depression Scale;pittsburgh sleep quality index;Instrumental Activities of daily Living scale;Activities of daily living scale; | — |
Countries
China
Contacts
Public ContactQiujun Wang
The Third Hospital of Hebei Medical University
Outcome results
None listed