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The effect of Evocumab in improving the progression of non-target lesions after PCI

The effect of Evocumab in improving the progression of non-target lesions after PCI:A single-center, randomized controlled study

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300070824
Enrollment
Unknown
Registered
2023-04-24
Start date
2023-05-01
Completion date
Unknown
Last updated
2023-06-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

coronary heart disease

Interventions

Routine statins combine with Evocumab:Routine statins combine with Evocumab
Routine statins:Routine statins

Sponsors

The Second Affiliated Hospital of Dalian Medical University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 85 Years

Inclusion criteria

Inclusion criteria: 1. Diagnosis of coronary heart disease; 2. PCI guided by IVUS; 3. Aged 18-85; 4. Patients or their family members sign informed consent.

Exclusion criteria

Exclusion criteria: 1) Liver, kidney, heart failure, tumor, systemic infection, autoimmune diseases, etc.; 2) Surgical history within 1 month before onset; 3) The patient had vasculitis, was in the active stage and had erythrocyte sedimentation rate >30ml/h; 4) Those who take inflammatory suppressive drugs, immunosuppressive drugs or hormone drugs; 5) Abnormal white blood cell count by routine blood test; 6) Coagulation disorders for any reason 7) Female subjects who are pregnant, lactating or have positive pregnancy test; Or had a birth plan within 6 months of the end of the trial.

Design outcomes

Primary

MeasureTime frame
Percent atheroma volume(PAV);

Secondary

MeasureTime frame
Total atheroma volume(TAV);MLA;NC ratio(NC%);VHTCFA;

Countries

China

Contacts

Public ContactJiajie Mei

The Second Affiliated Hospital of Dalian Medical University

meijiajie179@163.com+86 17709870815

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026