vascular mild cognitive impairment
Conditions
Interventions
Vascular cognitive impairment - Intervention group:Routine rehabilitation training + rTMS
Vascular cognitive impairment - Control group:Routine rehabilitation training
Sponsors
Nanjing Brain Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: All subjects were recruited through our hospital rehabilitation medicine clinic, wards and volunteers enrolled in 40 patients with VaMCI, 20 cases of normal controls, the subject is mainly based on the 2016 China Association of Aged Care Senile Dementia and Related Diseases Committee ( ADC ) developed diagnostic criteria. Specific criteria are : (1) Neuropsychological assessment confirmed the existence of cognitive impairment : damage identified in more than one cognitive domain or critical damage in more than two domains ( critical damage refers to the 5 % -10 % of the age-matched norm or 1.5 standard deviation of the norm mean ) ; (2) Structural imaging confirmed the presence of cerebrovascular disease, including multiple lacunar infarction, cerebral infarction in key areas and white matter lesions ; (3) There is a correlation between cerebrovascular disease and cognitive impairment or enough to constitute the cause of cognitive impairment [ such as cognitive impairment occurs within 3 months of cerebrovascular disease or Haginsky ischemic score ( HIS ) >= 7 points, or no cerebrovascular events, but there is evidence of significant decline in information processing speed and / or executive function, and one of the characteristics of gait, urine and personality abnormalities ] ; (4) Daily living ability belongs to the normal range ; (5) Does not meet the diagnostic criteria for dementia ; (6) Excluding other causes of cognitive impairment. The above 6 items are all consistent and can be diagnosed as VaMCI.
Exclusion criteria
Exclusion criteria: 1 Patients with cognitive impairment or other neurological diseases leading to cognitive decline, such as Alzheimer 's disease, Parkinson 's disease and Parkinson 's syndrome ; 2 patients with other serious physical diseases, metal implants such as cardiac pacemakers or skull defects ; 3 patients with severe visual, auditory and language disorders, pregnant women or lactating patients ; consciousness disorder, cerebral hemorrhage, severe mental illness history, severe epilepsy history, etc. ; 5 had received rTMS treatment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| functional magnetic resonance imaging;Cognitive Neuropsychological Scale; | — |
Countries
China
Contacts
Public ContactJiang Rao
Nanjing Brain Hospital
Outcome results
None listed