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Evaluation of GnRH antagonist pretreatment before ovarian stimulation in a GnRH antagonist protocol in poor ovarian response women undergoing IVF/ICSI: A randomized controlled trial

Evaluation of GnRH antagonist pretreatment before ovarian stimulation in a GnRH antagonist protocol in poor ovarian response women undergoing IVF/ICSI: A randomized controlled trial

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2300070803
Enrollment
Unknown
Registered
2023-04-24
Start date
2023-04-24
Completion date
Unknown
Last updated
2023-06-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

infertility

Interventions

pretreatment group :GnRH antagonist administration from day 1 of the menstrual cycle for 3 days

Sponsors

the People's Hospital of Guangxi Zhuang Autonomous Region
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
20 Years to 44 Years

Inclusion criteria

Inclusion criteria: 1)female age <45 years old, 2) bilateral ovaries exist and no hormone therapy has been given in recent 1 month, 3) endometrium is normal, 4)Low ovarian response as defined by the Bologna criteria

Exclusion criteria

Exclusion criteria: 1)Abnormal endocrine hormone, such as hyperprolactinemia, thyroid disease; 2)Endometrial lesions (endometrial polyps, history of intrauterine adhesions, etc.), uterine malformations, uterine fibroids (fibroids larger than 3cm or closely related to the endometriosis) 3)Endometriosis III-IV, adenomyosis, hydrotubal, etc; 4)History of recurrent abortion, repeated implantation failure, chromosomal abnormalities; 5)BMI>=30 kg/m2.

Design outcomes

Primary

MeasureTime frame
the number of retrieved oocytes;

Secondary

MeasureTime frame
Gn dose;Gn days;Number of mature eggs;fertilization rate;Good embryo number;implantation rate;clinical pregnancy rate;rate of abortion;live birth rate;

Countries

China

Contacts

Public ContactYisheng Zhang

the People's Hospital of Guangxi Zhuang Autonomous Region

175125941@qq.com+86 15177172501

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026