Thyroidectomy
Conditions
Interventions
opioid-free anaesthesia group:Patients in the opioid-free group will receive bilateral superficial cervical plexus block+dexmedetomidine+esketamine+propofol anesthesia.
opioid anesthesia group:The patients in the opioid anesthesia group will receive propofol combined with sufentanil and remifentanil anesthesia.
Sponsors
Department of Anesthesiology and Perioperative Medicine, Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients who undergo thyroid surgery on a selective basis regardless of gender; 2. Age 18-65 years old; ASAI-II level; 3. Voluntarily participate in the research and sign an informed consent form.
Exclusion criteria
Exclusion criteria: 1. Body mass index>30kg/?; 2. Those who have used analgesics and sedatives before surgery; 3. Suffering from unstable ischemic cardiomyopathy, pulmonary hypertension, uncontrolled hypertension (although undergoing antihypertensive treatment, systolic blood pressure>140mmhg or diastolic blood pressure>90mmhg when lying on the back); 4. Liver dysfunction (glutamic acid aminotransferase or aspartate aminotransferase value >= 2 times the upper normal limit or total bilirubin>1.5 times the upper normal limit); 5. Renal dysfunction (serum creatinine>=2mg/dl); 6. Patients with elevated intracranial and intraocular pressure; 7. Patients with a history of chronic pain; 8. Mental illness or alcohol abuse; 9. Individuals who are allergic to the drugs used in the study; 10. Pregnant and lactating patients; 11. Patients undergoing secondary surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The quality of recovery-15 score at 24 hours after surgery;Pain score for one months after sugery; | — |
Secondary
| Measure | Time frame |
|---|---|
| consumption of postoperative analgesics;Blood pressure, heart rate and oxygen saturation during operation;consumption of vasoactive agents;Pain scores at rest and movement;Sleep quality score at surgical night;Postoperative nausea and vomiting score;time first time to first ambulation after surgerydrinking and eating, and days in hospita;The quality of recovery score at 1month after sugery;duration of anesthesia and surgery;sedation scores at 10, 20, and 30 minutes;Measurement of salivary cortisol, C-reactive protein, and melatonin;time to first taking food and water;time of postoperative hospitalization;The quality of recovery score at 3month after sugery;Pain score for three months after sugery; | — |
Countries
China
Contacts
Public ContactWuYun
Department of Anesthesia and Perioperative Medicine, the Second Affiliated Hospital of Anhui Medical University
Outcome results
None listed