Autism-spectrum disorder
Conditions
Interventions
High dose group:Oral 40 billion cfu L. reuteri CICC6132
low-dose group:Oral 20 billion L. reuteri CICC6132
matched group :rehabilitation training
Sponsors
Dalian Women and Children's Medical Center (Group)
Eligibility
Sex/Gender
All
Age
2 Years to 6 Years
Inclusion criteria
Inclusion criteria: (1) Meet the diagnostic criteria for autism in the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) and the diagnostic criteria for Classification and Diagnosis of Mental Disorders (CCMD-2) version 2; (2) the Autism Rating Scale (Childhood autism rating scale, CARS) 30 points; (4) age 2-6 years, no gender limit;
Exclusion criteria
Exclusion criteria: (1) Excluding other extensive developmental disorders and genetic autism with clear causes; (2) Using antibiotics, probiotics or other gastrointestinal treatment within 1 month prior to enrollment; (3) Autism clinical overall impression scale score as lack of symptoms or mild symptoms; (4) Patients with epilepsy, ADHD and other comorbidities; (5) Any behavior that prevents the principal interpretation of clinical judgment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Infant-Junior High School Student’s Social Living Ability Scale,SM;Autism Behavior Checklist;ABC; | — |
Secondary
| Measure | Time frame |
|---|---|
| Trajectories of eye movements;childhood autism rating scale;CARS;child behavior checklist;CBCL; | — |
Countries
China
Contacts
Public ContactSun jin
Dalian Women and Children's Medical Center (Group)
Outcome results
None listed