anxiety and depression
Conditions
Interventions
Control group (H group):Group H used sufentanil 2ug/kg, added normal saline to prepare 150ml solution, pump speed 0.5ml/h, add 2ml, lock for 15min.
Esketamine Group 1 (ES-1 Group):In the ES-1 group, esketamine 1mg/kg combined with sufentanil 2ug/kg was added, and normal saline was added to prepare 150ml solution, pump speed 0.5ml/h, add 2ml, and
Esketamine Group 2 (ES-2 Group):In the ES-2 group, esketamine 2mg/kg combined with sufentanil 2ug/kg was added, and normal saline was added to prepare 150ml solution, pump speed 0.5ml/h, add 2ml, and
Sponsors
Medical Ethics Committee of Hainan Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1.ASA I~II 2.Age= 65 years 3.Elderly patients undergoing elective laparoscopic surgery for colorectal cancer. 4.Be able to understand the process and methods of this research and voluntarily participate in this research
Exclusion criteria
Exclusion criteria: 1. Those who refuse to participate in this study; 2. Those with contraindications to general anesthesia or have had general anesthesia accidents in the past; 3. Known or suspected allergy or contraindications to esketamine, propofol injection, opioids, muscle relaxants; 4. Uncontrolled hypertension, hypotension and diabetes patients; 5. History of alcohol or drug dependence; 6. Abuse or long-term application of anesthetic, sedative, analgesic drugs; 7. Those with previous mental illness; 8. Patients who have participated in other studies in the past 2 months; 9. Subjects who the investigator believes have other factors that are not suitable to participate in this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of anxiety and depression in the 24 hours postoperative period.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative 2h, 4h, 24hVAS scores;Sedation scores at 2h, 4h, and 24h postoperatively;Additional analgesia; | — |
Countries
China
Contacts
Public ContactRong Ding
Hainan General Hospital
Outcome results
None listed