sepsis
Conditions
Interventions
Group of infection:no
Sponsors
Shanghai general hospital
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: Eligible subjects to be enrolled in this study must meet all of the following criteria: 1. Age >= 18 years old, <= 85 years old, male and female; 2. Patients in intensive care unit; 3. Confirmed or clinically diagnosed infection; 4. Acute change in sequential organ failure score = 2 points, i.e. ?SOFA score = 2 points (baseline SOFA score for patients with unknown pre-existing organ dysfunction was 0); 5. Infection-related organ failure occurs within 48 hours; Organ failure was defined as a sequential organ failure score (SOFA) of = 2 in at least one organ or system in the circulatory, respiratory, kidney, liver, coagulation, and central nervous systems (i.e., a SOFA score of = 2 points emerging at any point in the screening period).
Exclusion criteria
Exclusion criteria: Subjects who meet any of the following criteria are not eligible for inclusion in this study. 1. Previous history of advanced malignant tumor and end-stage organ failure; 2. Previous history of bone marrow transplantation or solid organ transplantation such as liver and kidney; 3. Patients without lymphocyte count within 24h before and after enrollment; 4. The estimated survival time of patients is less than 72 hours; 5. Pregnant or nursing patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of 90-day poor prognosis; | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in the expression of lymphocyte subsets;28-day/hospitalization / 90-day mortality rate;days in ICU/days in hospital; | — |
Countries
China
Contacts
Public ContactZhou zhigang
Shanghai general hospital
Outcome results
None listed