COVID-19
Conditions
Interventions
experimental gruop:micro hyperbaric oxygen therapy + routine courese
control gruop:routine course
Sponsors
Naval Medical Center of PLA
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Age between 18~90 years old 2. Criteria for severe COVID-19 are met 3. Able to complete the operation of the micro hyperbaric chamber as required under guidance 4. No absolute contraindication to hyperbaric exposure 5. Sign the informed consent form
Exclusion criteria
Exclusion criteria: Patients with multiple rib fractures, severe and extensive chest wall contusions and untreated open chest wall trauma; (2) patients; (4) Patients with uncontrolled acute respiratory obstruction; (5) Patients with active tuberculosis with cavity formation Tension pneumothorax and spontaneous pneumothorax in untreated patients; (3) Severe obstructive pulmonary emphysema or still hemoptysis; (6) Patients with recently extracted teeth such as maxillary molars or cuspids; (7) Patients with purulent otitis media; (8) Non-congestive glaucoma patients; (9) Patients with retinal detachment; (10) Those with internal bleeding or uncontrolled bleeding disorders; (11) Untreated cancer patients. 2. Pregnant women. 3. Claustrophobic patients. 4. COVID-19 asymptomatic patients or patients with mild symptoms 5. Patients considered unsuitable for the trial for other reasons.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| WHO Clinical Progress Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Viral load (CT vale);Routine blood;interleukin-6;interleukin-1beta;C-reactive protein;TNF-alpha;d-dimer;Serum IgE;Serum IgG;lung imagine;duration of hospitalization;Arterial Blood Gas; | — |
Countries
China
Contacts
Public ContactYang Liu
Naval Medical Center of PLA
Outcome results
None listed