depression
Conditions
Interventions
trail:A unified therapeutic approach was used to intervene, including sleep titration, rapid antidepressant, and sleep regulation
Sponsors
Affiliated Hospital of Weifang Medical College
Eligibility
Sex/Gender
All
Age
12 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Meets the DMS-5 diagnostic criteria for depression, with a HAMD score of>=17 points; 2. Meets the ICSD-3 diagnostic criteria for insomnia, with difficulty in initiating or maintaining sleep, and a PSQI of>=8 points; 3. The patient voluntarily signs an informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients with contraindications to the use of ketamine, such as poorly controlled hypertension, hyperthyroidism, and elevated intracranial pressure; 2. Severe cardiopulmonary, liver and kidney diseases (chronic respiratory failure, heart failure, heart conduction block, renal failure, liver cirrhosis, etc.); 3. Those with severe neurological and psychiatric disorders who cannot cooperate with research.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hamilton depression scale,HAMD;fMRI; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hamilton Anxiety Scale,HAMA;Pittsburgh sleep quality index, PSQI;MOOD; | — |
Countries
china
Contacts
Public ContactAn Jianxiong
Affiliated Hospital of Weifang Medical College/ University of Chinese Academy of Sciences
Outcome results
None listed