Acute respiratory distress syndrome
Conditions
Interventions
Test group:Analgesic protocol using Esketamine
control group:Analgesia protocol using Remifentanil
Sponsors
Tangdu Hospital of the Fourth Military Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1) Age>18 2) Patients diagnosed with ARDS 3) Mechanical ventilation is required (according to the Clinical Application Guide of Mechanical Ventilation) and the expected ventilation time is>72h 4) Analgesic and sedative treatment is required 5) The client of the patient voluntarily signs the informed consent form
Exclusion criteria
Exclusion criteria: 1) Maternity 2) Known allergy to Esketamine 3) Patients with a history of dementia or mental illness or taking antipsychotic or antidepressant drugs at home 4) Respiratory diseases, such as lobectomy, rib fracture compression fixation 5) Take antihypertensive drugs irregularly, have poor blood pressure control (hypertension grade 2), have a history of tachycardia (heart rate>120 times/min), and risk of brain injury and intracranial hypertension 6) Take M receptor blockers and M receptor stimulants in the last three days; ß 2 receptor blocker 7) Treatment with neuromuscular junction blockers (NMBDs) 8) Extracorporeal membrane oxygenation (ECMO) support therapy 9) The patient gives up resuscitation or is expected to die within 24 hours 10)He has participated in other clinical trials within three months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| airway resistance;Static lung compliance;peak airway pressure;plateau pressure; | — |
Secondary
| Measure | Time frame |
|---|---|
| Oxygenation index;PaO2;PaCO2;SpO2;mean arterial pressure;PCT;IL-6;white blood cell count;Percentage of neutrophils; | — |
Countries
China
Contacts
Public ContactYao Linong
Tangdu Hospital of the Fourth Military Medical University
Outcome results
None listed