Viral pneumonia
Conditions
Interventions
Liugan Shuangjie Formula Group:Liugan Shuangjie Formulas
Liugan Shuangjie Granules Standard Dose Group:Liugan Shuangjie Granules Standard Dose
Liugan Shuangjie Granules High-Dose Group:Liugan Shuangjie Granules High-Dose
Liugan Shuangjie Granules Low-Dose Group:Liugan Shuangjie Granules Low-Dose
Antiviral Drug Group:Oseltamivir Capsules/ Paxlovid
Sponsors
Guangdong Provincial Hospital of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: (1)Age = 18 years old (2)Diagnostic criteria meet the viral pneumonia (3)Traditional Chinese medicine differentiation as Phlegm Heat Staying in the Lung Syndrome (4)Patient's clinical symptoms present with at least 2 of the following 5 main symptoms:fever, cough, sputum, dyspnea (shortness of breath), pleuritic chest pain (5)CURB-65 score of 0-3 (6)Patient informed and signed informed consent form
Exclusion criteria
Exclusion criteria: (1)Patients with severe pneumonia, multi-organ failure, acute respiratory distress syndrome, etc (2)Patients with hospital acquired pneumonia or ventilator associated pneumonia (3)Patients with other serious respiratory diseases, such as chronic obstructive pulmonary disease, bronchiectasis, active pulmonary tuberculosis, etc (4)Patients with severe basic diseases such as heart, brain, lung, liver, kidney, blood system diseases, and mental illness (5)Abnormal liver function[ALT or AST=2.0 ULN(upper limits of normal)] or renal dysfunction(serum creatinine =1.5 ULN) (6)Patients with immunodeficiency such as malignancy, organ or bone marrow transplantation, HIV infection or taking immunosuppressive drugs or glucocorticoids within the last 3 months (7)Patients with swallowing difficulties, patients who have undergone gastrectomy or combined with Crohn's disease and other diseases that severely affect gastrointestinal absorption (8)Patients who are pregnant, planning pregnancy and breastfeeding (9)Allergic, or known to be allergic to the ingredients of Liugan Shuangjie Granules and to the underlying therapeutic class of drugs (10)Patients who are participating in clinical trials of other drugs (11)Patients deemed unsuitable for clinical trials by researchers
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Early clinical symptom improvement rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical symptom cure rate;Modified Pneumonia Imaging Absorption Evaluation Scale;Cough and Sputum Assessment Questionnaire;CURB-65 rating;Scoring of Traditional Chinese Medicine Syndrome Efficacy;Viral antigen conversion rate; | — |
Countries
China
Contacts
Public ContactLin Lin
Guangdong Provincial Hospital of Traditional Chinese Medicine
Outcome results
None listed