Knee joint replacement
Conditions
Interventions
control group:The control group (group C) was given the same amount of normal saline.
Esketamine group:Esketamine group (group K) included midazolam 0.05 mg/kg, etomidate 0.3 mg/kg, sufentanil 0.5 ug/kg, rocuronium 0.6 mg/kg and esketamine 0.2 mg/kg. Anesthesia maintenance: Esketamine
Sponsors
Xuzhou Central Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. over 65 years old; 2. ASA grade I ~ III; 3. Elective knee replacement.
Exclusion criteria
Exclusion criteria: 1. There was cognitive dysfunction before operation (MMSE score <=24 after previous definite diagnosis/admission); 2. contraindications to esketamine (severe hypertension, tachycardia, hyperthyroidism, etc.); 3. Patients with severe heart, brain, lung, liver and kidney diseases; 4. Those who can't cooperate to complete the cognitive assessment; 5. Those who are participating in other clinical trials and those who refuse to participate in the trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of POCD; | — |
Secondary
| Measure | Time frame |
|---|---|
| IL-6?S100ß?NSE;Opioid drugs and propofol dosage;PACU residence time;Times of postoperative remedial analgesia;Incidence of adverse events (cardiovascular adverse events: hypertension, hypotension, tachycardia; Nausea and vomiting; Hypoxemia; Awakening delay; | — |
Countries
China
Contacts
Public Contactmeng xiangdi
Xuzhou Central Hospital
Outcome results
None listed