Cerebrovascular diseases
Conditions
Interventions
AS group, ASS group, AF group, AFS group:non-intervention
Sponsors
Affiliated Hospital of North Sichuan Medical College
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Patients with cerebral atherosclerosis without stroke: (1) have two or more CAS risk factors (such as advanced age, hypertension, hyperlipidemia, diabetes, smoking, etc.), or one CAS risk factor combined with definite corresponding clinical symptoms. (2) Ultrasonic examination: A. Carotid artery ultrasound found carotid intima-media thickness thickening > 1.0mm, or local plaque, or vascular stenosis/occlusion. B and TCD indicate plaque formation, or the discovery of any vessel stenosis, or any vessel occlusion. (3) MRA/CTA/DSA: arteriosclerosis changes can be seen, or plaque formation can be indicated, or any vessel stenosis can be found, or any vessel occlusion can be found. (4) Head CT or MRI showed no acute cerebral infarction foci. 2. Stroke patients caused by cerebral atherosclerosis: (1) Enrolled patients met the diagnostic criteria of 1), 2) and 3) cerebral atherosclerosis above. (2) Head CT or MRI indicates acute cerebral infarction. (3) Exclude cardiac embolism or other cerebral infarction of unknown etiology. 3. Patients clinically diagnosed with nonvalvular atrial fibrillation without stroke: A, electrocardiogram or 24-hour holter electrocardiogram indicated atrial fibrillation (defined as irregular atrial rhythm with a heart rate of more than 300 beats per minute and a duration of more than 30 seconds). B. On admission, head CT or MRI indicated no acute cerebral infarction lesion. 4. Stroke patients with atrial fibrillation: (1), age >18 years old, ECG indicated atrial fibrillation (atrial fibrillation definition: heart rate > 300 times/minute, duration of more than 30 seconds irregular atrial rhythm); (2) Cardiogenesis embolism was considered according to TOAST classification. Imaging (CT or MRI) showed that the diameter of cerebral cortex, brainstem, cerebellum or subcortical infarcts was greater than 1.5cm, with more than one vascular innervation area or evidence of multi-system embolization.
Exclusion criteria
Exclusion criteria: 1. Non-stroke group of atrial fibrillation: patients with valvular atrial fibrillation (defined as rheumatic valvular heart disease and atrial fibrillation after heart valve surgery), reversible atrial fibrillation (such as abnormal thyroid function, acute alcoholism, after surgery, etc.), accompanied by other arrhythmias, and previous history of stroke were excluded. 2. Atrial fibrillation stroke group: A. valvular atrial fibrillation (defined as rheumatic valvular heart disease and atrial fibrillation after heart valve surgery) should be excluded. B. Reversible atrial fibrillation (e.g., abnormal thyroid function, acute alcoholism, post-operative surgery, etc.), accompanied by other arrhythmias. C. Patients with non-cardiogenic embolism and unknown embolism need to be excluded, such as fat embolism, air embolism, cancer embolism, infectious pus embolism, parasite embolism, etc. Attention should be given to the identification of patients a, acute myocardial infarction, b, cancer, c, systemic lupus erythematosus, and d, antiphospholipid antibody syndrome. D. History of previous stroke. 3. Atherosclerosis without stroke group: atherosclerosis can be roughly divided into: intracranial atherosclerosis, carotid atherosclerosis, aortic atherosclerosis, peripheral atherosclerosis. cerebral infarction patients are mostly associated with the formation of atherosclerosis in the intracranial and neck, namely cerebral atherosclerosis. Therefore, in order to reduce the sample size and eliminate possible negative results, this study excluded: A. Only patients with aortic atherosclerosis were found. B. Only patients with peripheral atherosclerosis were found. 4. Atherosclerotic stroke group: excluded 1) cardiogenic stroke: A, potential source of cardiogenic embolus, risk factors for cardiogenic cerebral embolism: atrial fibrillation, heart valvular disease, rheumatic heart disease, dilated cardiomyopathy, left atrial or left atrial ear thrombosis, sick sinus syndrome, left atrial myxoma, infectious endocarditis, etc. B. Clinical manifestations: Sudden onset, peak within seconds or minutes, disturbance of consciousness at the onset, or rapid improvement of major neurological deficits at the early stage of the onset, more supportive of diagnosis. C. Angiographic examination confirmed no atherosclerotic stenosis of intracranial or extracranial large vessels corresponding to neurological function defect in cerebral infarction (> 50%), or multiple innervated vascular areas at the same time, or combined with other body organs embolism. 2) Other stroke of unknown etiology. 5. Hemorrhagic stroke should be ruled out in hospitalized patients: plain head CT examination showed areas of intracerebral high density hematoma, low density edema zone around hematoma and occupying effect.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Interleukin 4;CSF2; | — |
Secondary
| Measure | Time frame |
|---|---|
| CXCR4;MAPK3;NGF;IGF1R; | — |
Countries
China
Contacts
Public ContactGuoHui Jiang
Affiliated Hospital of North Sichuan Medical College
Outcome results
None listed