breast cancer
Conditions
Interventions
one:eskatamine0.125mg/kg
two:eskatamine0.25mg/kg
three:eskatamine0.5mg/kg
four:equal volume normal saline
Sponsors
Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Female patients undergoing radical mastectomy under elective general anesthesia; 2, State Anxiety Scale (SAI) > 37 points; 3, age: 18-65 years old; 4, ASA classification: I-III level; 5. Sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Obvious abnormality of heart, lung, liver and kidney function and abnormal coagulation function before operation; 2. People who have taken anti-anxiety drugs, antidepressants or sedatives for a long time; 3. Patients with poorly controlled or untreated hypertension ( >=180/110mmHg); 4, patients with increased intracranial pressure or intraocular pressure; 5. Untreated or undertreated patients with hyperthyroidism; 6. Patients who are allergic to drugs involved in this study; 7. Patients unable to complete the scales involved in this study; 8. Patients who have participated in other clinical studies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| State anxiety Inventory score on the third day after surgery;Pain scores on day 1, 3, and 7 after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| State anxiety Inventory scores on the first and seventh day after surgery;Trait anxiety Inventory score on the seventh day after surgery;Postoperative recovery quality scores on day 1, 3, and 7;Sleep quality scores on postoperative day 1, 3 and 7;Depression scores on day 1, 3, and 7 after surgery; | — |
Countries
China
Contacts
Public ContactChen Xiuxia
Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed