PPROM
Conditions
Interventions
Neonatal infection group:no
Control group:no
Maternal infection group:no
Neonatal infection and maternal infection group:no
Sponsors
Chongqing Health Center for Women and Children
Eligibility
Sex/Gender
Female
Age
20 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1.According to the diagnostic criteria of "Guidelines for Diagnosis and Management of premature Rupture of Membranes 2015 Edition" issued by the Obstetrics and Gynecology Branch of the Chinese Medical Association, pregnant women who received PPROM at the first diagnosis and were expected to receive treatment at less than 34 weeks of actual gestation were selected as the research objects. 2.Fully informed consent to participate in the study
Exclusion criteria
Exclusion criteria: 1.Gestational diabetes mellitus, gestational hypertension disease, gestational liver disease, fetal distress and other pregnancy complications. 2.Medical premature rupture of membranes. 3.syphilis, AIDS, hepatitis A and other infectious diseases.4.Received hormone, antibacterial drugs, probiotics, cytokines and other treatments in the past 1 month.5.Drug addict or heavy smoker. 6.Obesity, diabetes, hypertension, autoimmune diseases and malignant tumors before pregnancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| bacterial diversity;bacterial abundance;metabolic activity; | — |
Secondary
| Measure | Time frame |
|---|---|
| glycometabolism;nucleic acid synthesis; | — |
Countries
China
Contacts
Public Contactzhou wei
Chongqing Health Center for Women and Children
Outcome results
None listed