cancer
Conditions
Interventions
dexmedetomidine group:combined dexmedetomidine anesthesia and analgesia
control group:routine anesthesia and analgesia
Sponsors
Cancer Hospital Chinese Academy of Medical Sciences
Eligibility
Sex/Gender
All
Age
65 Years to 100 Years
Inclusion criteria
Inclusion criteria: Elderly patients aged 65 and above; ASA I-II; elective laparoscopic abdominal surgery, including gastrointestinal surgery and gynecologic surgery.
Exclusion criteria
Exclusion criteria: Anemia, hemoglobin 30kg/m2; combined with serious cardiovascular disease and respiratory disease; liver and kidney insufficiency; liver and urinary surgery, as well as surgery that will directly damage liver and kidney function; systemic or important organ infection; long term use of sedatives and analgesics; alcoholism; primary epilepsy or long-term use of antiepileptic drugs; long-term use of antipsychotic medication; allergies history of drugs used in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| blood immune cell transcriptome;blood plasma proteome; | — |
Secondary
| Measure | Time frame |
|---|---|
| postoperative recovery status;Genes related to blood oxidative stress/blood-brain barrier injury; | — |
Countries
China
Contacts
Public ContactCheng Ni
Cancer Hospital Chinese Academy of Medical Sciences
Outcome results
None listed