stroke
Conditions
Interventions
Ischemic semi-dark zone progression group:N/A
Non-ischemic semi-dark zone progression group:N/A
Sponsors
The First Affiliated Hospital of Wannan Medical College
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Adult (18 years or older). 2. ASPECTS score >=6 confirmed by the most recent brain tissue imaging after onset 3. clinically confirmed acute ischemic stroke in the anterior circulation with acute occlusion of the responsible vessel located in the intracranial segment of the internal carotid artery, the T bifurcation or the M1 segment of the middle cerebral artery. 4. mRS score < 2 before onset 5. time from onset to groin puncture < 24 hours 6. successful reperfusion (expanded Thrombolysis in Cerebral Infarction score 2c-3 (eTICI 2c-3)) 7. Informed consent signed by the patient himself or by the patient's legally authorized representative.
Exclusion criteria
Exclusion criteria: 1. Intracranial hemorrhagic disease as seen on cranial CT: hemorrhagic stroke, epidural hematoma, subdural hematoma, ventricular hemorrhage, subarachnoid hemorrhage, etc. 2. Known recent or current serum creatinine exceeding 1.5 times the upper limit of normal or an estimated glomerular filtration rate (eGFR) 38.0 degree, elevated white blood cells, diagnosis of pneumonia, and urinary tract infection at presentation or admission. 4. Patients with severe mental disorders or unable to cooperate in completing the informed consent and follow-up components due to dementia. 5. Patients with concurrent malignancy or with severe systemic disease with an expected survival of less than 90 days. 6. those who have participated in other interventional clinical studies within 30 days, or are participating in other interventional clinical studies postoperatively lost to follow-up
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Thrombosis metabolomics;Blood Metabolomics;Volume of ischemic semidark band; | — |
Secondary
| Measure | Time frame |
|---|---|
| 90-day neurological prognosis;Symptomatic intracranial hemorrhage;Deaths within 90 days;NIHSS score;GCS score;ASPECTS score;ASPECTS score; | — |
Countries
China
Contacts
Public ContactXianjun Huang
The First Affiliated Hospital of Wannan Medical College
Outcome results
None listed