Vitamin D deficency
Conditions
Interventions
A single intramuscular injection of vitamin D2:A single intramuscular injection of 600,000 units vitamin D2
Intermittent intramuscular injection of vitamin D2:Multiple intramuscular injection of vitamin D2, 600,000 units of vitamin D2 each time, until the subject's vitamin D level reaches sufficient state
Sponsors
The Second Xiangya Hospital, Central South University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1) 25-hydroxyvitamin D level < 20 ng/ml 2) Aged between 18 and 60 years 3) No liver or kidney dysfunction or other serious diseases 4) No long-term travel planned in the tropical region within 6 months after the trial started 5) Willingness to participate in this study and sign informed consent
Exclusion criteria
Exclusion criteria: 1) Vitamin D supplements in the last 6 months 2) A history of any drugs that could affect vitamin D metabolism in the last 6 months 3) Reluctance to participate in research 4) A history of cognitive impairment or somatic dysfunction affecting completion of study 5) A history of Hypercalcemia, vitamin D overdose or poisoning, renal insufficiency, chronic diarrhea, hypoproteinemia, or other conditions affecting vitamin D metabolism
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 25(OH)D2;25(OH)D3;25(OH)D;Serum calcium;Serum creatinine;24-hour urinary calcium;24-hour urine creatinine;Body fat mass;Body lean mass;Bone mineral density; | — |
Secondary
| Measure | Time frame |
|---|---|
| Serum osteocalcin;Serum parathyroid hormone;Serum ß-C-terminaltelopeptide typeIcollagen;Serum N-terminal propeptide of type I procollagen; | — |
Countries
China
Contacts
Public ContactZhongjian Xie
National Clinical Research Center for Metabolic Diseases, the Second Xiangya Hospital, Central South University
Outcome results
None listed