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Study on the mechanism of liposarcoma-derived exosomes mediating macrophage polarization in tumor microenvironment

Study on the mechanism of liposarcoma-derived exosomes mediating macrophage polarization in tumor microenvironment

Status
Recruiting
Phases
Early Phase 1
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2300070624
Enrollment
Unknown
Registered
2023-04-18
Start date
2022-08-20
Completion date
Unknown
Last updated
2023-06-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Retroperitoneal tumor

Interventions

Patient with tumor tissue group:N/A
Patients with paratumoral adipose group:N/A

Sponsors

West China Hosipital of Sichuan University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1) Dedifferentiated liposarcoma was first diagnosed by pathological biopsy; 2) Recurrent patients diagnosed with dedifferentiated liposarcoma; 3) Sign relevant informed consent and be willing to participate in the study

Exclusion criteria

Exclusion criteria: a) Patients with highly differentiated, mucous or pleomorphic liposarcoma were pathologically diagnosed b) Mentally ill or subjectively unable to cooperate c) The patient refused surgical resection and requested conservative treatment d) Women who are breastfeeding or pregnant, or women or men who are planning to have children in the near future e) Life expectancy =2.5 mg/dL in the 30 days before surgery, or on dialysis) j) Diagnosis of active systemic infection or uncontrolled coagulopathy within 14 days before surgery

Design outcomes

Primary

MeasureTime frame
The expression level of target gene related mRNA;Protein levels of target genes in liposarcoma tissues;

Secondary

MeasureTime frame
The expression of related proteins of target gene-related mRNA;Cell proliferation;

Countries

China

Contacts

Public ContactJichun Zhao

Department of Vascular Surgery, West China Hospital, Sichuan University

zhaojc6@126.com+86 18980601368

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026